• Users Online: 231
  • Home
  • Print this page
  • Email this page
Home About us ASMR Conference Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 14  |  Issue : 1  |  Page : 25-32

Protective effect of Hypericum perforatum on dexamethasone-induced diabetic depression in rats


1 Department of Research on Children with Special Needs, National Research Centre, Giza, Egypt
2 Department of Pharmacology, National Research Centre, Giza, Egypt
3 Department of Medical Physiology, National Research Centre, Giza, Egypt
4 Department of Pathology, National Research Centre, Giza, Egypt

Correspondence Address:
Mohamed E Elhadidy
Department of Research on Children with Special Needs, National Research Centre, El-Bouhouth St., Giza, 12622
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jasmr.jasmr_7_19

Rights and Permissions

Background/aim Complex interactions among psychological, social, and biological factors are the reason for diabetic depression. The present study was designed to evaluate the effect of Hypericum perforatum extract on dexamethasone-induced diabetic depression. Materials and methods A total of 24 adult male Wistar rats were divided into four groups (six rats each): group 1: control; group 2: daily treated with dexamethasone (0.44 mg/kg; intraperitoneally for 28 days); and groups 3 and 4: daily treated with H. perforatum extract (100 and 200 mg/kg; orally) concurrent with dexamethasone injection for 15 consecutive days. Plasma levels of blood glucose, glucose transporter-2, CD4, total antioxidant capacity, malondialdehyde, and nitric oxide were measured. In addition, the brain contents of serotonin, dopamine, cyclooxygenase-2, and transforming growth factor-β1 were determined. Moreover, assessment of histopathological changes of brain tissues and immunohistochemical analysis of caspase-9 were performed. Results Significant elevations were recorded in blood glucose level and plasma levels of malondialdehyde and nitric oxide. In addition, brain contents of dopamine, transforming growth factor-β1, and cyclooxygenase-2 were increased significantly in dexamethasone-treated group. However, plasma levels of glucose transporter-2, CD4, and total antioxidant capacity and the brain content of serotonin were significantly decreased in comparison with control group. Both doses of H. perforatum significantly ameliorated all biochemical parameters and alleviated histopathological and immunohistochemical apoptotic changes induced by dexamethasone in the rat cortex, striatum, and hippocampus. Conclusion H. perforatum extract possesses antioxidant, anti-inflammatory, and immunomodulatory effects against dexamethasone-induced diabetic depression.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed116    
    Printed10    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal