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ORIGINAL ARTICLE
Year : 2019  |  Volume : 14  |  Issue : 2  |  Page : 153-161

Immunohistochemical expression of CD4+ and CD8+ tumor-infiltrating lymphocytes in colorectal carcinoma


Department of Pathology, National Research Centre, Cairo, Egypt

Correspondence Address:
Manal A Badawi
MD of Pathology, Department of Pathology, Medical Research Division, NRC, Elbohooth Street, Dokki Cairo 12622
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jasmr.jasmr_22_19

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Background/aim Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the world. The potential influences of tumor-infiltrating lymphocytes (TILs) in various neoplasms including CRC have been reported to reflect the antitumor immunity of the host. The aim of this study was to evaluate the expression of CD4+ and CD8+ TILs in CRC and to correlate their expression with patients’ clinicopathological parameters. Materials and methods Paraffin blocks and clinicopathological data of 130 patients with CRC were obtained from private laboratories. The density of CD4 and CD8 tumor TILs was assessed immunohistochemically and evaluated by image analysis in 130 specimens of CRC. The CD4+and CD8+ cell tumor infiltrate was classified into scanty, moderate, and abundant expression. Results Of the 130 CRC cases, 68 (66.2%) were adenocarcinoma and 44 (33.8%) were mucinous carcinoma, 114 (87.7%) were of grade II and 16 (12.3%) were of tumor grade III. CD4+ T cells expression was significantly correlated with the histopathological grade and Duke’s classification. CD8+ T cells expression was significantly correlated with the Duke’s classification. Conclusion Cancer colon progression is influenced by host immune response and the presence of TILs CD4+ and CD8+. Further studies are recommended to assess implication of these cells in CRC prognosis.


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