• Users Online: 122
  • Home
  • Print this page
  • Email this page
Home About us ASMR Conference Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 1  |  Page : 12-18

Study of the possible cardioprotective effects of insulin, ATP, and L-arginine against isoproterenol-induced myocardial infarction


Department of Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Mona A. Ahmed
Department of Physiology, Faculty of Medicine, Ain Shams University, 74 Abbassiya Street, Abdou Pasha Square, 11517 Cairo
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background/Aim Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide. The present study was carried out to investigate the possible protective effects of insulin, ATP, and L-arginine on cardiac dysfunction in experimental isoproterenol (ISO)-induced myocardial infarction (MI), aiming at achieving useful means for protection and therapy against MI. Materials and methods Wistar rats of both sexes were allocated into five groups: the control group, the untreated MI group, and MI groups treated with insulin, ATP, or L-arginine. All rats were subjected to ECG recording, and plasma levels of troponin I and triglycerides were determined. The isolated perfused hearts, according to Langendorff's preparation, were studied; the left ventricular weight (LV) was determined, and the LV per body weight ratio (LV/BW) was calculated. Results The percentage mortality and total arrhythmia were significantly reduced upon treatment with ATP and L-arginine. The ST segment elevation was significantly reduced in insulin-treated rats. The QRS duration and QTo intervals were significantly decreased in ATP-treated and L-arginine-treated rats, and the QTc interval was significantly shortened in all three treated groups. The levels of plasma triglycerides significantly reduced on treatment with insulin and ATP. In the three treated groups, the peak developed tension baseline value and maximal response were significantly increased when compared with the untreated group. In addition, the half-relaxation time baseline value was significantly decreased in the treated groups when compared with the control group. The myocardial flow rate baseline value and maximal response were significantly increased on L-arginine treatment. The LV weights and LV/BW ratios were significantly increased in all three treated groups. Conclusion Insulin, ATP, and L-arginine were variably effective in partially modifying the ISO-induced MI insults and offered partial protection against ISO-induced myocardial damage.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed585    
    Printed48    
    Emailed0    
    PDF Downloaded83    
    Comments [Add]    

Recommend this journal