• Users Online: 60
  • Home
  • Print this page
  • Email this page
Home About us ASMR Conference Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 74-78

Effect of smoking on skin elastic fibers: a morphometric and immunohistochemical analysis

1 Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Dermatology and Venereology, National Research Centre, Cairo, Egypt
3 Department of Pathology, National Research Centre, Cairo, Egypt

Correspondence Address:
Abdel Razik H Farrag
Department of Pathology, National Research Centre, Dokki, Zip Code: 12622; Cairo
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1687-4293.123790

Rights and Permissions

Background/aim Tobacco smoking is one of the major health problems in the world. This study was conducted to investigate the morphological changes of the dermal elastic tissue of sun-protected skin induced by smoking. Participants and methods Punch biopsies were obtained from the nonexposed skin of 15 smokers and 15 nonsmokers to evaluate the dermal elastic fibers using morphometric analysis and immunohistochemical techniques. Results Elastic fibers of the reticular dermis were more numerous, thickened and fragmented in smokers than in nonsmokers. Correlations between the cumulative tobacco dose and the morphology of the elastic fibers were highly significant. Immunohistochemical analysis for α-1-antitrypsin showed negative cytoplasmic staining for all samples of both smokers and nonsmokers. Conclusion This study indicates that smoking is one of the risk factors that lead to an increase in elastic fibers of the reticular dermis. This increase is due to elastic tissue degradation rather than by new synthesis, as in solar elastosis. Furthermore, smoking has multiplicative effects on facial ageing and could share, at least in part, a pathophysiological pathway.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded138    
    Comments [Add]    

Recommend this journal