Year : 2014 | Volume
: 9 | Issue : 1 | Page : 15--22
Biochemical evaluation of renal osteodystrophy in uraemic patients
Maha H Mohamed1, Magda S Mahmoud1, Mohamed D.E. Abd El-Maksoud1, Tamer E Mosa1, Adel A Ali2
1 Department of Biochemistry, National Research Centre, Cairo, Egypt
2 Department of Internal Medicine, Faculty of Medicine, Alazhr University, Cairo, Egypt
Renal osteodystrophy is a multifactorial disorder of bone remodelling that develops in patients with chronic renal failure (CRF). Biochemical markers of bone turnover have been proposed for the noninvasive diagnosis of renal osteodystrophy. The purpose of this study was to evaluate intact parathyroid hormone (iPTH) and some markers of bone disease in predialysis (preD) and haemodialysis (HD) CRF patients and correlate them with bone mineral density (BMD).
Patients and methods
Several biochemical markers were measured in the serum of 74 CRF patients (38 preD patients and 36 patients on regular HD). In addition, 30 healthy volunteers were included as controls. BMD of all patients was measured by means of calcaneal ultrasonography.
BMD was measured by means of ultrasound. BMD was significantly decreased in both patient groups when compared with controls. Also, it was significantly lower in patients with osteoporosis than in those with osteopenia. iPTH, total alkaline phosphatase (ALP) and osteocalcin (OC) levels were significantly elevated in both patient groups when compared with controls. Ionized calcium (Ca 2+ ), free carnitine and insulin-like growth factor-1 (IGF-1) levels were significantly decreased in patients compared with controls. There was a significant inverse correlation of BMD with iPTH, ALP and OC and a significant positive correlation with Ca 2+ and IGF-1 in HD patients. PreD patients showed significant inverse correlation of BMD with iPTH and ALP and significant positive correlation with Ca 2+ .
The results of the present study suggested that ultrasound is a useful method for evaluating BMD and provides information about diverse regional skeletal changes in CRF patients. iPTH, ALP, OC and Ca 2+ can predict renal osteodystrophy in preD and HD CRF patients. PreD and HD CRF patients often have low serum concentrations of free carnitine and IGF-1.
Mohamed D.E. Abd El-Maksoud
PhD, Biochemistry Department, National Research Centre, Cairo
|How to cite this article:|
Mohamed MH, Mahmoud MS, Abd El-Maksoud MD, Mosa TE, Ali AA. Biochemical evaluation of renal osteodystrophy in uraemic patients.J Arab Soc Med Res 2014;9:15-22
|How to cite this URL:|
Mohamed MH, Mahmoud MS, Abd El-Maksoud MD, Mosa TE, Ali AA. Biochemical evaluation of renal osteodystrophy in uraemic patients. J Arab Soc Med Res [serial online] 2014 [cited 2021 Oct 17 ];9:15-22
Available from: http://www.new.asmr.eg.net/article.asp?issn=1687-4293;year=2014;volume=9;issue=1;spage=15;epage=22;aulast=Mohamed;type=0