Figure 4 Photomicrographs of brain sections in control, control extract, and AD group. (a, b, c) Group 1: brain section of normal control rat showing the cerebellum with normal histological features, illustrating a well-defined molecular layer (black arrow), presence of numerous closely packed small cells in the granular layer (red arrow), and large Purkinje cells in the Purkinje cell layer (yellow arrow). (d, e, f) Group 2: control extract showing the cerebellum with normal histological features: a well-defined molecular layer, numerous closely packed small cells in the granular layer, and large Purkinje cells in the Purkinje cell layer. (g, h, i) Group 3: brain section of AD group, showing cerebellum with marked distortion in granular cell layer (sparse cell distribution), sparse cell distribution of Purkinje layers, and marked reduction in cellular size of the molecular layer, as well as moderate edema and interstitial neuronal atrophy and shrinkage (green arrow) (hematoxylin and eosin stain, ×100, ×400, ×400). AD, Alzheimer’s disease.